Friday, April 17, 2020

Antiviral said to knock out Covid fast;
experts assail 'flawed' computer model

From Statnews:
A Chicago hospital treating severe Covid-19 patients with Gilead Sciences’ antiviral medicine remdesivir in a closely watched clinical trial is seeing rapid recoveries in fever and respiratory symptoms, with nearly all patients discharged in less than a week, STAT has learned.

Remdesivir was one of the first medicines identified as having the potential to impact SARS-CoV-2, the novel coronavirus that causes Covid-19, in lab tests. The entire world has been waiting for results from Gilead’s clinical trials, and positive results would likely lead to fast approvals by the Food and Drug Administration and other regulatory agencies. If safe and effective, it could become the first approved treatment against the disease.

The University of Chicago Medicine recruited 125 people with Covid-19 into Gilead’s two Phase 3 clinical trials. Of those people, 113 had severe disease. All the patients have been treated with daily infusions of remdesivir.

“The best news is that most of our patients have already been discharged, which is great. We’ve only had two patients perish,” said Kathleen Mullane, the University of Chicago infectious disease specialist overseeing the remdesivir studies for the hospital.
The mortality rate of 1.6% is close to the rate for those who die in hospital of flu, though the figures are not precisely comparable.

In another Covid development reported by Statnews, many epidemiologists are harshly criticizing the Covid model used by White House experts, arguing that it has proved highly unreliable and hence dangerous for use in decision-making. White House experts had been using Covid death projections from the Institute for Health Metrics and Evaluation (IHME), which terms itself an "independent global health research center at the University of Washington."

This reporter, citing years of journalistic experience, can attest that epidemiologists tend toward iconoclasm, not being highly prone to agreement in their statements to the public.

Antiviral looks like a wonder drug
https://www.statnews.com/2020/04/16/early-peek-at-data-on-gilead-coronavirus-drug-suggests-patients-are-responding-to-treatment/

Flawed Covid model slammed
https://www.statnews.com/2020/04/17/influential-covid-19-model-uses-flawed-methods-shouldnt-guide-policies-critics-say/

No comments:

Post a Comment

NEWS of the WORLD launched

The Invisible Man is being folded into the new site, NEWS of the WORLD, which has begun operation. Though this Invisible Man site is ce...